Roorkee, 12th November 2020: Amid the rapid transmission of COVID-19, a group of scientists from IIT Roorkee, led by Prof. Soumitra Satapathi have leveraged Artificial Intelligence (AI) to predict 10 FDI- approved commercial drugs available for the treatment of the disease. The study has been published in the prestigious journal PLOS One. The other co-authors of the study include Sovesh Mohapatra, Prathul Nath, Manisha Chatterjee, Neeladrisingha Das, Deepjyoti Kalita and Partha Roy.
The complexity in drug design and protocols regarding clinical trials often inhibit the process of developing various new drug combinations for the disease. IIT Roorkee scientists have successfully deployed Machine Learning-based-AI techniques to predict the commercial drugs that could be used for the treatment of COVID-19.
"Our study predicts around ten FDA approved commercial drugs that can be used for the treatment," says Prof. Satapathi, Principal Investigator and an Associate Professor of Physics in IIT Roorkee.
Many of the predicted drugs are already in use for the treatment of COVID-19, and some are in trials.
"Given the need of the present time, the present approach will save a lot of resources and time for synthesizing novel drugs and thus will be useful for a vast majority of the medical research community," Prof. Satapathi added.
The Machine Learning (ML) model based on the naive Bayes algorithm was used to predict the drugs that could be used for the treatment of COVID-19. The study shows that around ten FDA approved commercial drugs can be used for repurposing. Among all, it has also been found that the antiretroviral drug Amprenavir would probably be the most effective drug based on the selected criterions.
IIT Roorkee is an institute of national importance imparting higher education in engineering, sciences, management, architecture and planning, and humanities and social sciences. Since its establishment in 1847, the Institute has played a vital role in providing technical human resources and know-how to the country.
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